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|Title: ||Determining the efficiency of malaria rapid diagnostic test to diagnose post transfusion malaria in children under five years old at Komfo Anokye Teaching Hospital|
|Authors: ||Bouaré, Djénèba|
|Issue Date: ||3-Nov-2015|
|Abstract: ||Malaria associated with blood transfusion in malaria-endemic countries has until recently been
a neglected area. Malaria prophylaxis has however been consistently used for the management
of transfusion transmitted malaria (TTM). Current recommendations from World Health
Organization (WHO) state that, the diagnosis of malaria must be confirmed before initiation of
therapy. It is therefore important to establish which of the current routine test methods, is most
appropriate for use. Malaria RDTs are now supplementing microscopy in the diagnosis of
malaria in many endemic countries. However their efficiency as a screening tool for the
detection of malaria in donors or in transfusion recipients has not been well evaluated.
The aim of this study was to determine the efficiency of malaria RDT in the detection of post
transfusion malaria in children under five years old at Komfo Anokye Teaching Hospital
The study took place between November 2014 and April 2015. Blood samples from 179
patients and their corresponding donors were tested for Plasmodium parasitaemia using RDT
and microscopy. The recipients’ blood samples were obtained within 48hours after transfusion
for malaria diagnosis. To determine the incidence of post transfusion malaria, 32 patients were
purposefully selected. Their pre-transfusion, post transfusion and donor blood samples were
tested for malaria using PCR.
Majority (52%) of the study population was between the ages of 0 - < 1 year. Prevalence of
malaria in blood donors was 27% by RDT and 7% by microscopy. Prevalence at pre transfusion,
was 34% by RDT and 13% by microscopy. Prevalence at post transfusion was 59% by RDT
and 4% by microscopy. Incidence of post transfusion malaria by PCR was 57%. The sensitivity
of RDT in detecting malaria at post transfusion was 100%. Efficiency of malaria RDT as a tool
for malaria diagnosis at post transfusion, among children under five years old is good.
Clinicians should consider implementing the use of malaria RDT at post transfusion.|
|Description: ||A thesis submitted to the Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology in partial fulfilment of the requirement for the degree of MASTER OF SCIENCE ,School of Medical Sciences, College of Health Sciences, 2015|
|Appears in Collections:||College of Health Sciences|
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