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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/8028

Title: Biochemical and haematological responses of HIV patients co-infected with hepatitis b virus and hepatitis c virus to antiretroviral therapy
Authors: Anyimah, Isaac Owusu
Issue Date: 5-Nov-2015
Abstract: Background: The introduction of antiretroviral therapy has considerably helped improve the life expectancy of Human Immunodeficiency Virus (HIV)-infected patients. This notwithstanding, the antiretroviral therapy (ART) has also been found to induce some biochemical and haematological abnormality in some HIV-infected patients. The ART-induced biochemical and haematological abnormality is noted to be sometime s complicated by co-infection with other pathogens such as, Hepatitis B Virus and Hepatitis C Virus. Aim: The aim, therefore, was to determine the biochemical and haematological responses in HIV-infected patients on antiretroviral therapy and those also co-infected with hepatitis B Virus or hepatitis C Virus in the Tarkwa-Nsuaem Municipality. Methods: A hospital-based prospective cohort study was conducted on 125 HIV patients from February, 2014 to May, 2015 at the Tarkwa Government Hospital. Data on socio-demography and exposure to risk factors associated with HBV and HCV co-infection were collected using structured questionnaire. Venous blood samples were collected from the participants for Hepatitis B surface antigen (HBsAg) and anti-HCV tests. Biochemical and haematological indices were obtained by estimation with Vitalab Selectra Junior Automatic chemistry analyzer and KX-21N Sysmex Automatic Haematology Analyzer. The biochemical and haematological parameters compared were haemoglobin (Hb) concentration, total white blood cell (WBC) count and lymphocyte counts and aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and urea, respectively. Comparison was made between the mean at pre-ART and at 6-month and 12-month post ART using two sample t-test at 5% level of significance. Results: Of the 125 HIV-infected patients included in the study, 39(31.20%) were males and 86(68.80%) were females with mean age (SD±) 38 (±9.7) years. The prevalence of HBV, HCV and HBV/HCV co-infection among the HIV patients were 22(17.60%), 9(7.20%) and 2(1.60%) respectively. Logistics regression analysis of history of exposure to multiple sexual partners, exposure to sharp objects, such as razor blades shared with others, exposure to tattoo, exposure to blood transfusion and exposure to intravenous drug revealed no significant association with HBV or HCV co-infection among the HIV patients. Serum urea increased significantly (p < 0.01) among patients infected with HIV alone at post ART. There was no significant difference in the Hb concentration, total WBC, Lymphocyte counts, AST, ALT, Urea and Creatinine concentrations between HIV patients co-infected with HBV or HCV and those without the co-infection. Conclusion: Biochemical and haematological responses of HIV patients on ART are not affected by co-infection with Hepatitis B Virus or Hepatitis C Virus. Limitation: Hepatitis B envelope antigen (HBeAg) and Deoxyribonucleic acid (DNA) were not tested to assess the stage of liver disease.
Description: A thesis submitted to the Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology in fulfillment for the requirements of the degree of Master of Philosophy, 2015
URI: http://hdl.handle.net/123456789/8028
Appears in Collections:College of Health Sciences

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