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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/9486

Title: The effect of intermittent preventive treatment using sulphadoxine pyrimethamine in control of malaria in pregnancy: A cross-sectional study in the Offinso district of Ghana
Authors: Lawson, Bernard
Browne, Edmund
Brown, Charles
Larbi, John
Osei Tutu, Emmanuel
Osei Tutu, Emmanuel
Keywords: Malaria
intermittent preventive treatment
pregnant women
sulphadoxine-pyrimethamine
Issue Date: Jun-2010
Publisher: Journal of Public Health and Epidemiology
Citation: Journal of Public Health and Epidemiology Vol. 2(3), pp. 53-59, June 2010
Abstract: Malaria infection during pregnancy causes maternal anaemia and placental parasitaemia both of which pose substantial risks to the mother, the foetus and the newborn. This study assessed the effects of intermittent preventive treatment (IPTp) using Sulphadoxine-Pyrimethamine (SP) to control malaria in pregnancy in the Offinso district, Ghana. Pregnant women attending antenatal clinics (ANC) between October 2005 and June 2006 in five health facilities in the District were studied. The effects of SP on parasitaemia, haemoglobin level and adverse effects on pregnant women were assessed. Of the 444 pregnant women studied, 190 (43%) took SP. The influence of SP intake on malaria infection was insignificant (r = 0.0008, p = 0.986). However, there was a tendency towards reduced parasitaemia as number of SP doses increased; one dose: 29/82 (35%), two doses: 18/57 (32%) and three doses: 11/57 (22%). The mean Hb level (10.4 ± 1.69 g/dl) for the SP group (all doses combined) was significantly higher than that (9.9 ± 1.64 g/dl) in the no SP group (p = 0.002). Further, there was a significant association between IPTp using SP and haemoglobin level (p = 0.01) with a dose-response relationship. SP usage had no significant adverse effects on the pregnant women. Effective implementation of IPTp using SP is an evidence-based measure for control of malaria-related anaemia in pregnancy.
Description: This Article was published by Journal of Public Health and Epidemiology Vol. 2(3), pp. 53-59, June 2010
URI: http://hdl.handle.net/123456789/9486
Appears in Collections:College of Health Sciences

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