DSpace
 

KNUSTSpace >
Research Articles >
College of Science >

Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/9644

Title: Association between Anemia and Aflatoxin B 1 Biomarker Levels among Pregnant Women in Kumasi, Ghana
Authors: Williams, Jonathan H.
Wilson, Craig
Person, Sharina D.
Funkhouser, Ellen
Yatich, Nelly J.
Stiles, Jonathan K.
Ellis, William Otoo
Jiang, Yi
Ehiri, John E.
Jolly, Pauline E.
Shuaib, Faisal M. B.
Issue Date: 2010
Publisher: Am. J. Trop. Med. Hyg
Citation: Am. J. Trop. Med. Hyg., 83(5), 2010, pp. 1077–1083 doi:10.4269/ajtmh.2010.09-0772 Copyright © 2010 by The American Society of Tropical Medicine and Hygiene
Abstract: Aflatoxins are fungal metabolites that contaminate staple food crops in many developing countries. Up to 40% of women attending a prenatal clinic in Africa may be anemic. In a cross-sectional study of 755 pregnant women, Aflatoxin B 1 -lysine adducts (AF-ALB) levels were determined by high-performance liquid chromatography. Participants were divided into quartiles “low,” “moderate,” “high,” and “very high.” Anemia was defined as hemoglobin levels < 11 g/dL. Logistic regression was used to examine the association of anemia with AF-ALB. The mean AF-ALB level was 10.9 pg/mg (range = 0.44–268.73 pg/mg); 30.3% of participants were anemic. The odds of being anemic increased 21% (odds ratio [OR], 1.21, P = 0.01) with each quartile of AF-ALB reaching an 85% increased odds in the “very high” compared with the “low” category (OR, 1.85; confidence interval [CI], 1.16–2.95). This association was stronger among women with malaria and findings were robust when women with evidence of iron deficiency anemia were excluded. This study found a strong, consistent association between anemia in pregnancy and aflatoxins.
Description: This Article was published by Am. J. Trop. Med. Hyg., 83(5), 2010, pp. 1077–1083 doi:10.4269/ajtmh.2010.09-0772 Copyright © 2010 by The American Society of Tropical Medicine and Hygiene
URI: http://hdl.handle.net/123456789/9644
Appears in Collections:College of Science

Files in This Item:

File Description SizeFormat
Association between anemia and aflatoxin B1 biomarker levels among pregnant women in Kumasi, Ghana.pdf448.16 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback