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|Title: ||Association between Anemia and Aflatoxin B 1 Biomarker Levels among Pregnant Women in Kumasi, Ghana|
|Authors: ||Williams, Jonathan H.|
Person, Sharina D.
Yatich, Nelly J.
Stiles, Jonathan K.
Ellis, William Otoo
Ehiri, John E.
Jolly, Pauline E.
Shuaib, Faisal M. B.
|Issue Date: ||2010|
|Publisher: ||Am. J. Trop. Med. Hyg|
|Citation: ||Am. J. Trop. Med. Hyg., 83(5), 2010, pp. 1077–1083 doi:10.4269/ajtmh.2010.09-0772 Copyright © 2010 by The American Society of Tropical Medicine and Hygiene|
|Abstract: ||Aflatoxins are fungal metabolites that contaminate staple food crops in many developing countries. Up to
40% of women attending a prenatal clinic in Africa may be anemic. In a cross-sectional study of 755 pregnant women,
Aflatoxin B 1 -lysine adducts (AF-ALB) levels were determined by high-performance liquid chromatography. Participants
were divided into quartiles “low,” “moderate,” “high,” and “very high.” Anemia was defined as hemoglobin levels < 11 g/dL.
Logistic regression was used to examine the association of anemia with AF-ALB. The mean AF-ALB level was 10.9 pg/mg
(range = 0.44–268.73 pg/mg); 30.3% of participants were anemic. The odds of being anemic increased 21% (odds ratio [OR],
1.21, P = 0.01) with each quartile of AF-ALB reaching an 85% increased odds in the “very high” compared with the “low”
category (OR, 1.85; confidence interval [CI], 1.16–2.95). This association was stronger among women with malaria and findings
were robust when women with evidence of iron deficiency anemia were excluded. This study found a strong, consistent
association between anemia in pregnancy and aflatoxins.|
|Description: ||This Article was published by Am. J. Trop. Med. Hyg., 83(5), 2010, pp. 1077–1083 doi:10.4269/ajtmh.2010.09-0772 Copyright © 2010 by The American Society of Tropical Medicine and Hygiene|
|Appears in Collections:||College of Science|
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