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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/9681

Title: NovaSil clay does not affect the concentrations of vitamins A and E and nutrient minerals in serum samples from Ghanaians at high risk for aflatoxicosis.
Authors: Phillips, T.D.
Wang, J.S.
Williams, J.H.
Ofori-Adjei, D.
Brattin, B.
Taylor, R.
Ellis, William Otoo
Jolly, P.E.
Huebner, H.J.
Guan, H.
Tang, L.
Johnson, N.M.
Xu, L.
Ankrah, N.A.
Wang, Z.
Afriyie-Gyawu, E.
Keywords: heavy metals
minerals
vitamin E
vitamin A
micronutrients
enterosorbent
aflatoxin
NovaSil clay
Issue Date: 25-Jul-2008
Publisher: Food Additives & Contaminants
Citation: Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jul;25(7):872-84. doi: 10.1080/02652030701854758.
Abstract: To assess the potential interference of NovaSil (NS) clay with micronutrients in humans, vitamins A and E and minerals (15 nutrient and 15 non-nutrient minerals) were measured in serum samples from a 3-month intervention trial with NS. Participants (n¼177) were randomly divided into three groups that received 3.0 g NS day 1 (high dose, HD), 1.5 g NS day 1 (low dose, LD), or placebo (PL). Levels of vitamins A and E in serum were comparable among the three study groups at baseline, 1 month and 3 months of NS intervention. Genderstratified non-parametric mixed-effect model analysis showed no significant effects of dose and dose–time interaction for levels of vitamins A and E. A significant time effect was detected; however, it was limited to an increase in vitamin E in the male participants over the course of the study. No significant differences were found in levels of the nutrient and non-nutrient minerals between the HD and PL groups at baseline and 3 months of NS intervention, except for strontium levels. Strontium was significantly increased (p<0.001) in the HD group (male¼113.65 28.00 mg l 1; female¼116.40 24.26 mg l 1) compared with the PL group (male¼83.55 39.90 mg l 1; female¼90.47 25.68 mg l 1) following the 3-month intervention with NS. These results, combined with safety and efficacy data, confirm that NS clay is highly effective in reducing aflatoxin exposure and acts as a selective enterosorbent that does not affect the serum concentrations of important vitamins and nutrient minerals in humans.
Description: This Article was published by Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jul;25(7):872-84. doi: 10.1080/02652030701854758.
URI: http://hdl.handle.net/123456789/9681
Appears in Collections:College of Science

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