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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/9938

Title: Sialic Acid, Metabolic and Anthropometric variables in type two diabetic patients.
Authors: Larbi, Albert
Issue Date: 18-Jan-2017
Abstract: Type 2 diabetes mellitus is associated with higher cardiovascular risk partly related to an increase in inflammatory parameters. There is however a gap in the fight to early detection of microvascular complications in type 2 diabetes in Ghana. The objective of this study was to determine the relationship between sialic acid with metabolic variables in Ghanaian type 2 diabetes with and without microvascular complications. This case-control study comprising of 150 type 2 diabetic patients and 50 age-matched healthy individuals without diabetes were recruited. Fasting venous blood samples were collected and analyzed for total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, fasting glucose, glycated hemoglobin, sialic acid and C-reactive protein. Serum sialic acid levels were elevated in diabetic with retinopathy (230.68 ± 135.60mg/dl) followed by nephropathy (196.53 ± 61.19mg/dl) compared to diabetic patients with no complications (185.55 ± 75.69mg/dl) (p=0.065). Patients with type two diabetes had significantly higher C-reactive protein (p=0.026) and serum sialic acid (p<0.0001) compared to the non-diabetics. In the patients with diabetes, 14.7% were able to excellently control their blood glucose with 28.0% poorly controlling their glycaemia. Level of Serum sialic acid was higher in the patients with good control than those with poor control. However, C-reactive was higher in patients with poor control and lower in those with good control. The inflammatory markers showed no statistically significant difference on comparison. No statistically significant relationship (P>0.05) was established between the levels of serum sialic acid and blood glucose and glycated haemoglobin among patients with diabetes. C-reactive was inversely associated with blood glucose though not statistically significant, whereas it was directly associated with glycated. Serum sialic acid and C-reactive protein both showed inverse relationship with total cholesterol levels, triglycerides and low lipoprotein. However, a direct relationship between serum sialic acid and high density lipoprotein with no significance (r= 0.018, P=0.825) was observed. The main findings of this study is that raised serum sialic acid concentration is strongly related to the presence of microvascular complications in type two diabetes particularly retinopathy and nephropathy. Again this study indicated direct association of glycated with elevation of serum sialic acid and C-reactive protein. These may imply a significant relation between inflammation and glycemic control in people with established diabetes.
Description: Thesis submitted to the Department of Molecular Medicine, School of Medical Sciences College of Health in partial fulfilment of the requirements for the Award of Master of Philosophy in Chemical Pathology, 2016
URI: http://hdl.handle.net/123456789/9938
Appears in Collections:College of Health Sciences

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