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|Title: ||Assessing the stability of Paediatric oral formulations prepared at Komfo Anokye Teaching Hospital (KATH)|
|Authors: ||Mbabila, Dick Baba|
|Issue Date: ||18-Jan-2017|
|Abstract: ||The study was carried out to determine the microbiological and chemical stability limits of paediatric formulations prepared in Komfo Anokye Teaching Hospital. It was also to determine the microbiological stability of buffer syrup of CMC which could be used as a base or vehicle for paediatric formulations.
Suspensions of eight formulations of paediatric dosages (acetazolamide, spironolactone, propranolol, furosemide, phenobarbitone, hydroxyurea, carbamazepine and lamivudine) were formulated according to the Komfo Anokye Teaching Hospital formulation procedure; the formulations were analysed chemically using HPLC methods and microbiologically by the Agar plate method within 120days.
The outcome showed that formulated suspensions of spironolactone and furosemide were microbiologically and chemically stable up to 30 days. Lamivudine suspension was stable chemically and microbiologically up to 60 days. The acetazolamide suspension was not stable up to 30 days contrary to a study reported by Nahata, 2003, though syrpalta was used as the vehicle or base in that research work. Phenobarbitone and propranolol suspensions were highly unstable within30 days therefore refrigeration of these suspensions is necessary to maintain their stability.
The buffer syrup of CMC was microbiologically stable up to one year, therefore can be formulated as ready to use base or vehicle for paediatric preparations.|
|Description: ||A thesis submitted to the Department of Pharmaceutics, Kwame Nkrumah
University of Science and Technology in partial fulfilment of the
Requirements for the degree of
Master of Science
Faculty of Pharmacy and Pharmaceutical Sciences,
College of Health Sciences, 2016.|
|Appears in Collections:||College of Health Sciences|
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