Isolation, identification and some chemical biological studies on compound funifenne from Tillacora Funifera (Menispermaceae) and Isolation, characterization and some chemical studies of the constituents of the plant Warbugia Salutaris (Canellaceae)

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dc.contributor.authorOwusu-Dapaah, George
dc.date.accessioned2012-04-16T03:57:52Z
dc.date.accessioned2023-04-19T21:26:03Z
dc.date.available2012-04-16T03:57:52Z
dc.date.available2023-04-19T21:26:03Z
dc.date.issued1993-09-16
dc.descriptionA thesis submitted to the Board of Postgraduate Studies, Kwame Nkrumah University of Science and Technology, Kumasi, in partial fulfilment of the requirements for the award of the Degree of Master of Science in Pharmacy, 1993en_US
dc.description.abstractA review of tumours and antitumour agents have been included in the work. Bisbenzylisoquinolines as a whole have been reviewed and special emphasis has been placed on the bisbenzylisoquinolines from Tiliacora and Triclisia species. A detail review has also been presented on funiferine. Physico-chemical analysis has been carried out on funiferine and this included partition coefficient, pKa and rate of quaternization determinations. Two derivatives of funiferine, 0-methyl and 0-Isopropyl derivatives were synthesized. The Brine shrimp lethality Bioassay has been carried out on funiferine, 00methylfuniferine and 0-isopropylfuniferine as a preliminary cytotoxicity test. The structure-activity relationship of these related compounds have been established and in the order. 0-isopropylfuniferine > 0-methylfuniferine > funiferine.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/3564
dc.language.isoenen_US
dc.relation.ispartofseries1967;
dc.titleIsolation, identification and some chemical biological studies on compound funifenne from Tillacora Funifera (Menispermaceae) and Isolation, characterization and some chemical studies of the constituents of the plant Warbugia Salutaris (Canellaceae)en_US
dc.typeThesisen_US
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