Isolation, identification and some chemical and biological studies on the compound funiferine from Tiliacora Funifera (Menispermaceae) and isolation, characterization and some chemical studies of the constituents of the plant Warbugia Salutaris (Canellaceae)

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dc.contributor.authorOwusu-Dapaah, George
dc.date.accessioned2011-11-08T21:39:09Z
dc.date.accessioned2023-04-19T05:43:56Z
dc.date.available2011-11-08T21:39:09Z
dc.date.available2023-04-19T05:43:56Z
dc.date.issued1993-11-08
dc.descriptionA thesis submitted to the College of Health Sciences in partial fulfillment of the requirement for the Degree of Master of Pharmacy, 1993en_US
dc.description.abstractA review of tumors and antitumor agents have been included in the work. Bisbenzylisoquinolines as a whole have been reviewed and special emphasis have been placed on the bisbenzylisoquinolines from Tiliacora and Triclisia species. A detail review have also been presented on funiferine. Physico-chemical analysis have been carried out on funiferine and this included partition coefficient, pKa and rate of quaternization determinations. Two derivatives of funiferine, 0-methyl and 0-Isopropyl derivatives, were synthesized. The Brine shrimp lethality Bioassay has been carried out on funiferine, 0-methylfuniferine and 0-isopropylfuniferine as a preliminary cytotoxicity test. The structure-activity relationship of these related compounds have been established and in the order. 0—isopropylfuniferine > 0—methylfuniferine > funiferine.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/1651
dc.language.isoenen_US
dc.relation.ispartofseries1967;
dc.titleIsolation, identification and some chemical and biological studies on the compound funiferine from Tiliacora Funifera (Menispermaceae) and isolation, characterization and some chemical studies of the constituents of the plant Warbugia Salutaris (Canellaceae)en_US
dc.typeThesisen_US
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