Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis

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dc.contributor.authorAwuah Afum-Adjei Anthony
dc.contributor.authorUeberberg Bianca
dc.contributor.authorOwusu-Dabo Ellis
dc.contributor.authorFrempong Margaret
dc.contributor.authorJacobsen Marc
dc.date.accessioned2023-12-06T14:33:39Z
dc.date.available2023-12-06T14:33:39Z
dc.date.issued2014
dc.descriptionThis article is published by International Immunology and is also available at https://doi.org/10.1093/intimm/dxu068
dc.description.abstractIFN-γ is crucial for protection against Mycobacterium tuberculosis. miR-29 was recently shown to non-redundantly inhibit IFN-γ. Here, we investigated IFN-γ and miR-29a expression dynamics of CD4+ T cells from patients during active tuberculosis (TB) (n = 32) and in household contacts who were latently M. tuberculosis infected (n = 19) from Ghana. Whereas M. tuberculosis-specific IFN γ expression was similar during TB chemotherapy, superantigen stimulation indicated generally impaired IFN-γ expression in TB patients. No interdependency between miR-29a and IFN-γ expression of T cells was observed. However, miR-29a was differentially expressed in T cells during chemotherapy. We concluded that differential miR-29a expression in active TB was not causative for impaired IFN-γ expression.
dc.description.sponsorshipKNUST
dc.identifier.citationInternational Immunology, Vol. 26, No. 10, pp. 579–582 doi:10.1093/intimm/dxu068 Advance Access publication 30 June 2014
dc.identifier.uri10.1093/intimm/dxu068
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/14674
dc.language.isoen
dc.publisherInternational Immunology
dc.titleDynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis
dc.typeArticle
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