Browsing by Author "Larbie, Christopher"
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- ItemHepatoprotective Potential of Hura crepitans L.: A Review of Ethnomedical, Phytochemical and Pharmacological Studies(Journal of Complementary and Alternative Medical Research, 2020-03) Owojuyigbe, Oluwole S.; Firempong, Caleb K.; Larbie, Christopher; Komlaga, Gustav; Emikpe, Benjamin O.Herbal medicines are the main source of treatment of diseases in non-urban centres of the developing world. Secondary metabolites obtained from herbal sources contain bioactive phytochemicals, many of which have been the origin for the development of novel pharmaceutical drugs. Hura crepitans L. (Euphorbiaceae) or sandbox tree has been beneficial in many ethnomedicinal applications as a purgative, emetic, hepatoprotective, anti-inflammatory, antimicrobial and the treatment of leprosy. Toxicological, phytochemical and bactericidal studies have also been documented. This paper reviews the potential of the Hura crepitans plant in protecting the liver against drug-induced toxicity. The paper dwells extensively on the ethnomedical, phytochemical and pharmacological properties of the plant. In achieving the above, intensive analyses of books and published peer-reviewed journal articles were carried out using credible scientific databases. Four main phytochemicals were revealed to be contained in Hura crepitans stem-bark. Their protective effects were enunciated using animal models. However much more biochemical studies need to be done to establish the hepatoprotective potentials of the various parts and various phytochemicals of Hura crepitans with the need for more preclinical and clinical studies. We, therefore, present in this paper efforts to elucidate and bring to the fore the therapeutic potentials of Hura crepitans plant.
- ItemHydroethanolic Extracts of Ficus pumila Linn. Is Protective against Gentamicin-Induced Kidney Damage in Rats(Journal of Advances in Medical and Pharmaceutical Sciences, 2018-06) Larbie, Christopher; Siaw, Portia A; Zon, Solomon; Appiah-Kubi, KwameN(3%1(2 Linn. has been reported to be rich in phenols, hepatoprotective and antiproliferative on leukemic cancer cells. The aim of this study was to evaluate the nephroprotective effect of hydroethanolic leaves extracts of N5%1(2 on gentamicin-induced kidney damage in rats. Twentyseven female Wistar albino rats were divided into 9 groups (n=3). Group 1 being normal; group 2 was the gentamicin (GM) induced only (80 mg/kg b/w ip for 5 days); groups 3, 4, & 5 rats were treated with gentamicin (80mg/kg b/w ip for 5 days) and N5%1(2 extract at 100, 250, and 500 mg/kg b/w orally respectively; groups 6, 7 & 8 rats received the extract only (100, 250, and 500 mg/kg b/w orally) respectively and group 9 being gentamicin and silymarin (100 mg/kg b/w orally) for 21 days. Blood samples were taken 24 hrs after the experimented period and biochemical and haematological parameters were analyzed. GM nephrotoxicity was characterized by significantly increased levels of serum creatinine, urea, sodium, potassium and WBC, while reduced RBC, HGB, MCH and MCV levels compared with normal group. Rats treated with gentamicin and the extract showed a significant reduction in the levels of these markers. The results suggest that hydroethanolic extract of N(3%1(2 leaves protect against gentamicin-induced nephrotoxicity in female Wistar albino rats.