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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/11928

Title: CD27 expression of T-cells discriminates IGRA-negative TB patients from healthy contacts in Ghana
Authors: Phillips, Richard O.
Adankwah, Ernest
Güler, Alptekin
Mayatepek, Ertan
Nausch, Norman
et. al
Keywords: Tuberculosis
Healthy contacts
IFN-g release assay
Issue Date: 2019
Publisher: Elsevier Masson SAS
Citation: Elsevier Masson SAS doi.org/10.1016/j.micinf.2019.07.003
Abstract: IFN-g release assays (IGRAs) have suboptimal sensitivity for detection of Mycobacterium tuberculosis (Mtb) infection and cannot discriminate between tuberculosis (TB) patients and healthy -potentially Mtb infected- contacts (HCs). In a case-control study, we determined T-cell phenotypes of IGRAs in TB patients (n ¼ 20) and HCs (n ¼ 20) from Ghana. CD27 expression of T-cells was significantly lower in TB patients as compared to HCs independent from Mtb-specificity. CD27 expression discriminated both study groups - including TB patients with low or indeterminate IGRA results - effectively. We conclude that CD27 is a promising biomarker for diagnosis of TB patients with inconclusive IGRA results.
Description: An article published by Elsevier Masson SAS
URI: http://hdl.handle.net/123456789/11928
Appears in Collections:College of Health Sciences

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