Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis
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Date
2014
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International Immunology
Abstract
IFN-γ is crucial for protection against Mycobacterium tuberculosis. miR-29 was recently shown to
non-redundantly inhibit IFN-γ. Here, we investigated IFN-γ and miR-29a expression dynamics of
CD4+ T cells from patients during active tuberculosis (TB) (n = 32) and in household contacts who
were latently M. tuberculosis infected (n = 19) from Ghana. Whereas M. tuberculosis-specific IFN γ
expression was similar during TB chemotherapy, superantigen stimulation indicated generally
impaired IFN-γ expression in TB patients. No interdependency between miR-29a and IFN-γ
expression of T cells was observed. However, miR-29a was differentially expressed in T cells during
chemotherapy. We concluded that differential miR-29a expression in active TB was not causative for
impaired IFN-γ expression.
Description
This article is published by International Immunology and is also available at https://doi.org/10.1093/intimm/dxu068
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Citation
International Immunology, Vol. 26, No. 10, pp. 579–582 doi:10.1093/intimm/dxu068 Advance Access publication 30 June 2014