MODELING THE INFECTION DYNAMICS OF ONCHOCERCIASIS AND ITS TREATMENT

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dc.contributor.authorOMONDI, EVANS OTIENO
dc.contributor.authorNYABADZA, FARAI
dc.contributor.authorBONYAH, EBENEZER
dc.contributor.authorBADU, KINGSLEY
dc.date.accessioned2020-06-22T12:13:38Z
dc.date.accessioned2023-04-19T02:03:35Z
dc.date.available2020-06-22T12:13:38Z
dc.date.available2023-04-19T02:03:35Z
dc.date.issued2017-04-05
dc.descriptionAn article published by World Scientific Publishing Company and also available at DOI: 10.1142/S0218339017500139en_US
dc.description.abstractOnchocerciasis is one of the neglected tropical diseases caused by Onchocerca volvulus. Ivermectin is known to be effective in the treatment of onchocerciasis because it suppresses the production of microfilariae by the adult female worms for a few months following treatment thus reducing transmission. In this study, a deterministic model is developed to assess the effect of mass treatment of onchocerciasis with ivermectin. The basic reproduction number, R0, of the model system is determined and it is observed that the model exhibits backward bifurcation for some parameters implying the existence of multiple endemic equilibria when R0 < 1. The existence of multiple equilibria emphasizes the fact that R0 < 1 is not sufficient to eradicate the disease and the need is to lower R0 much below one to make the disease-free equilibrium globally stable. Numerical simulations are done and conclusions drawn with respect to the known treatment protocols in endemic areas. The study results suggest that the mass treatment of the disease with ivermectin should cover a higher proportion of the population to control the disease and eventually eliminate it from the population.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.citationJournal of Biological Systems, Vol. 25, No. 2 (2017) 1–31 c World Scientific Publishing Company DOI: 10.1142/S0218339017500139en_US
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/12504
dc.language.isoenen_US
dc.publisherWorld Scientific Publishing Companyen_US
dc.subjectOnchocerciasisen_US
dc.subjectIvermectinen_US
dc.subjectMicrofilariaeen_US
dc.subjectMathematical modelen_US
dc.subjectSimulationsen_US
dc.titleMODELING THE INFECTION DYNAMICS OF ONCHOCERCIASIS AND ITS TREATMENTen_US
dc.typeArticleen_US
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