EVALUATION OF THE ANTI - PROLIFERATIVE EFFECT, ANTIOXIDANT AND PHYTOCHEMICAL CONSTITUENTS OF FICUS PUMILA LINN

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dc.contributor.authorTorkornoo, Dennis
dc.contributor.authorLarbie, Christopher
dc.contributor.authorAgbenyegah, Sefakor
dc.contributor.authorDowuona, Jasmine Naa Norkor
dc.contributor.authorAppiah-Oppong, Regina
dc.contributor.authorDotse, Eunice
dc.contributor.authorAning, Abigail
dc.contributor.authorAdu, Bright
dc.contributor.authorSinclear, Caleb
dc.date.accessioned2020-09-28T13:59:43Z
dc.date.accessioned2023-04-19T02:15:31Z
dc.date.available2020-09-28T13:59:43Z
dc.date.available2023-04-19T02:15:31Z
dc.date.issued2019-05
dc.descriptionThis artcle is published in International Journal of Phamaceutical Sciences and Research and also available at DOI: 10.13040/IJPSR.0975-8232en_US
dc.description.abstractThis study sought to evaluate the heavy metal content of the raw powder and extract of the plant, the phytochemical constituents, antioxidant effect by the use of DPPH assay, the total phenolic content using Folin Ciocalteu assay and the cytotoxic effect using the MTT Assay of Ficus pumila ethanolic extract, methanolic and hydro fractions on liver cancer cells (HepG2), Leukemic cells (Jurkat) and normal liver cells (Chang). FTIR and Gas ChromatographyMass Spectrometry (GC-MS) was used to identify the functional groups and major constituents of the most active fraction of F. pumila. Alkaloids, terpenoids, flavonoids, cardiac glycoside, saponins, and tannins were present in the ethanolic extract of F. pumila. The heavy metal analysis revealed the presence of Iron in both the raw powder (1.97 ± 0.11 mg/l) and extract (0.92 ± 0.02 mg/L). Zinc was also detected in both the raw powder (1.19 ± 0.00 mg/l) and extract (0.6595 ± 0.02 mg/l). The results from the FTIR revealed the presence of alkynes, alkyl halides, aromatics and aliphatic amines common to all fractions and compounds such as Phenol, 2,4-bis (1,1-Dimethylethyl) and Dodecane, 2,6, 10-trimethyl were detected in the samples by GC-MS. The DPPH assay also showed that all the fractions scavenged DPPH free radical in a dose-dependent manner as compared to the positive control (Ascorbic acid) and positively correlated to the phenolic contents. The MTT assay revealed that methanolic fraction was selective towards the Jurkat cell lines (Selectivity Index = 2.822). This increases the prospects that this plant contains compound(s) which could serve as leads for novel anticancer drugs.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.citationInternational Journal of Phamaceutical Sciences and Research, , Volume 10, Issue 5en_US
dc.identifier.uri10.13040/IJPSR.0975-8232
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/13108
dc.language.isoenen_US
dc.publisherInternational Journal of Phamaceutical Sciences and Researchen_US
dc.subjectFicus pumilaen_US
dc.subjectPhytochemicalsen_US
dc.subjectCytotoxicityen_US
dc.subjectAntioxidanten_US
dc.subjectCanceren_US
dc.subjectSelectivityen_US
dc.titleEVALUATION OF THE ANTI - PROLIFERATIVE EFFECT, ANTIOXIDANT AND PHYTOCHEMICAL CONSTITUENTS OF FICUS PUMILA LINNen_US
dc.typeArticleen_US
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