Browsing by Author "Asamoah-Boadi, Helen"

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    Biochemical and Haematological Profile of Diabetic Nephropathy
    (JULY, 2012) Asamoah-Boadi, Helen
    Background: Diabetic nephropathy, a microvascular complication of diabetes mellitus is now considered to be the leading known cause of end-stage renal disease (ESRD) in most countries. The objective of this study is to establish the haematological and biochemical profile of patients with diabetic nephropathy, so as to gain as much knowledge as possible about the disease, to help prevent the complication where possible and improve the quality of life of those affected. Method: A total of 101 type 2 diabetics with microalbuminuria (63) and overt nephropathy (38) were recruited for the study. 52 diabetics without nephropathy were recruited as controls. Structured questionnaires were administered to them and their venous blood samples taken for biochemical and haematological assays. Results: The mean age of the study group was 57.5 (± 9.6) years. Duration of disease and systolic blood pressure were significantly higher in the patient group (p<0.05). Total WBC and neutrophil count were also significantly higher in the patient group as compared to controls. Fasting blood sugar, serum albumin, globulin, total cholesterol and LDL cholesterol were found to be significantly higher in the patient group (p<0.05). Serum urea, creatinine, sodium, chloride and total iron were also significantly higher in the group. eGFR and serum vitamin B12 were found to be significantly lower in the patient group. Conclusion: Diabetics who develop microalbuminuria and nephropathy have several haematological and biochemical abnormalities, and these should be assessed and analysed periodically to help effectively manage their conditions.