Browsing by Author "Brobbey, A. A."

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    Antitrypanosomal and Anthelminthic Properties of Ethanol Extracts of Carica papaya Linn. and Ceiba pentandra (L) Gaertn
    (Hindawi, 2022) Obeng, A. W.; Boakye, Y. D.; Boamah, V. E.; Oppong-Kyekyeku,J; Brobbey, A. A.; et al.
    The most common diseases that affect low-income countries are helminthosis and trypanosomosis. In Ghana, and in many other African countries, herbal treatment of various diseases is still common. In the present study, we sought to determine the antitrypanosomal and anthelminthic activities of Carica papaya and Ceiba pentandra. The ethanol extracts of Carica papaya stem bark (PPSe) and leaves (PPLe) and ethanol extracts of Ceiba pentandra stem bark (CPSe) and leaves (CPLe) were screened against Trypanosoma brucei brucei and Pheretima posthuma worms in vitro. CPSe exhibited strong antitrypanosomal activity, while the other extracts exhibited moderate activity against T. b. brucei. All the extracts showed weak selective indices (SI) when tested on Jurkat cell lines, which is indicative of a potential toxic effect. When the extracts were screened against P. posthuma worms, only PPSe and CPSe were able to kill the worms after the exposure time at concentrations of 2.5, 5, and 10 mg/mL. PPSe was again the only extract that potentiated the anthelminthic activity of albendazole against P. posthuma worms. Preliminary phytochemical screening and GC-MS analysis revealed the presence of compounds with antitrypanosomal and anthelminthic properties. The results confirmed the potential of C. papaya and C. pentandra as remedies for trypanosomosis and helminthosis and also gives credence to their folkloric use.
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    Evaluation of acid neutralizing and buffering capacities of selected antacids in Ghana
    (Elsevier, 2020) Ayensu, Isaac; Bekoe, S. O.; Adu, J. K.; Brobbey, A. A.; Appiah, E.
    This study has evaluated the acid neutralizing and buffering capacities (BC) of nine selected antacid brands (“L1-L9”) in Ghana. The active acid neutralizing ingredients were recorded and the preliminary antacid test (PAT) determined with 0.5 N HCl after 10 min. The acid neutralizing capacity (ANC) was evaluated with 1 N HCl by neutralizing the excess with 0.5 N NaOH after 15 min stirring. Buffering capacity (BC) was estimated with 0.1 N HCl and titrated with 0.1 N NaOH at 5 min interval up to 50 min. All determination were at 37±3 °C using a pH meter. All brands had as part of their active ingredients dried aluminum hydroxide and magnesium hydroxide, with 67% containing simethicone as antifoam. The PAT declared all brands to be antacids with pH range of 4.38 ± 0.21– 6.43 ± 0.06. The ANC of all brands were in the range 13.16 ± 0.55–20.70 ± 0.18 mEq/g with “L4” and “L9” having the lowest and highest values respectively. “L9” further demonstrated a considerably higher BC up to 40 min whiles “L6” had the least BC up to 15 min. The ability of an antacid to have a high ANC and to resist significant changes in pH (longer BC) is crucial in assuring quality and efficacy of the brand.