Browsing by Author "Firempong, Caleb K."

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    Glycemic index of different varieties of yam as influenced by boiling, frying and roasting
    (Food Science & Nutrition, 2021) Ampofo, Deborah; Agbenorhevi, Jacob K.; Firempong, Caleb K.; Adu-Kwarteng, Evelyn; 0000-0002-8516-7656; 0000-0002-1358-125X
    Yam is one of the commonly consumed carbohydrate staples. The objective of this work was to investigate the effect of boiling, roasting, and frying on the glycemic index (GI) of white yam (Dioscorea rotundata), yellow yam (Dioscorea cayenesis), and water yam (Dioscorea alata). Yam tubers were obtained (peeled, sliced, washed) deep fried in vegetable oil for 35–40 min and boiled in water for about 35–45 min. Sliced unpeeled tubers were also roasted at about 120°C for 40–45 min. The cooked yam samples were fed to 10 healthy subjects aged between 20–50 years. A glucometer was used to measure the blood glucose concentrations of the test individuals before consuming the yam diets and after the 15th, 30th, 45th, 60th, 90th, and 120th min of consumption. The average incremental area under the curves (IAUC) obtained from the recorded blood glucose concentrations were used to calculate the GI of various yam diets. The GI of the yam diets were found to be in the following increasing order: White-yam-boiled (44.26%) < Water-yam-boiled (50.12%) < White-yam-roasted (50.62%) < Water-yam-roasted (54.04%) < White-yam-fried (59.13%) < Yellow-yam fried (65.08%) < Water-yam-fried (69.16%) < Yellow-yam-roasted (70.62%) < Yellowyam-boiled (75.18%). White yam diets relatively had lower GI compared to yellow yam and water yam. Boiling was found to give generally lower GI in the white and water yams and could therefore be applied in the preparation of lower GI diets for diabetics.
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    Hepatoprotective Potential of Hura crepitans L.: A Review of Ethnomedical, Phytochemical and Pharmacological Studies
    (Journal of Complementary and Alternative Medical Research, 2020-03) Owojuyigbe, Oluwole S.; Firempong, Caleb K.; Larbie, Christopher; Komlaga, Gustav; Emikpe, Benjamin O.
    Herbal medicines are the main source of treatment of diseases in non-urban centres of the developing world. Secondary metabolites obtained from herbal sources contain bioactive phytochemicals, many of which have been the origin for the development of novel pharmaceutical drugs. Hura crepitans L. (Euphorbiaceae) or sandbox tree has been beneficial in many ethnomedicinal applications as a purgative, emetic, hepatoprotective, anti-inflammatory, antimicrobial and the treatment of leprosy. Toxicological, phytochemical and bactericidal studies have also been documented. This paper reviews the potential of the Hura crepitans plant in protecting the liver against drug-induced toxicity. The paper dwells extensively on the ethnomedical, phytochemical and pharmacological properties of the plant. In achieving the above, intensive analyses of books and published peer-reviewed journal articles were carried out using credible scientific databases. Four main phytochemicals were revealed to be contained in Hura crepitans stem-bark. Their protective effects were enunciated using animal models. However much more biochemical studies need to be done to establish the hepatoprotective potentials of the various parts and various phytochemicals of Hura crepitans with the need for more preclinical and clinical studies. We, therefore, present in this paper efforts to elucidate and bring to the fore the therapeutic potentials of Hura crepitans plant.