Browsing by Author "Frempong Margaret"

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    Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis
    (International Immunology, 2014) Awuah Afum-Adjei Anthony; Ueberberg Bianca; Owusu-Dabo Ellis; Frempong Margaret; Jacobsen Marc
    IFN-γ is crucial for protection against Mycobacterium tuberculosis. miR-29 was recently shown to non-redundantly inhibit IFN-γ. Here, we investigated IFN-γ and miR-29a expression dynamics of CD4+ T cells from patients during active tuberculosis (TB) (n = 32) and in household contacts who were latently M. tuberculosis infected (n = 19) from Ghana. Whereas M. tuberculosis-specific IFN γ expression was similar during TB chemotherapy, superantigen stimulation indicated generally impaired IFN-γ expression in TB patients. No interdependency between miR-29a and IFN-γ expression of T cells was observed. However, miR-29a was differentially expressed in T cells during chemotherapy. We concluded that differential miR-29a expression in active TB was not causative for impaired IFN-γ expression.