Browsing by Author "Makhubela, Banothile C. E."

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    Water-soluble SNS cationic palladium(II) complexes and theirSuzuki–Miyaura cross-coupling reactions in aqueous medium
    (Beilstein-Institut, 2018-07-23) Fiebor, Alphonse; Tia, Richard; Makhubela, Banothile C. E.; Kinfe, Henok H.
    Unlike their SCS analogues, SNS pincer complexes are poorly studied for their use in coupling reactions. Accordingly, a series ofwater soluble cationic Pd(II) SNS pincer complexes have been successfully synthesised and investigated in detail for their catalyticactivity in Suzuki–Miyaura coupling reactions. By using only 0.5 mol % loading of the complexes, the coupling of inactivated arylbromides and activated aryl chlorides with various boronic acids in water was achieved in excellent yields and the catalysts werefound to be reusable for three cycles without a significant loss of activity. The investigation of the mechanism of the reactionrevealed that a Pd(II) to Pd(IV) route is the more likely pathway which was further supported by computational studies.