Browsing by Author "Osei Tutu, L"

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    Determinants of Late Presentation and Histologic types of Breast Cancer in Women Presenting at a Teaching Hospital in Kumasi, Ghana
    (MedCrave, 2015-11-13) Mensah, S; Dogbe, J; Kyei, I; Addofoh, N; Paintsil, V; Osei Tutu, L
    Breast cancer is the most common malignancy in women and the leading cause of cancer deaths worldwide. In Ghana and many parts of Africa more than 50% of breast cancer patients present with advanced stage even though evidence suggests that health education on breast cancer has intensified. Objectives: To determine the socio demographic characteristics of women presenting with breast cancer, pattern of presentation and the association between patients demographic characteristics and stage of presentation. Methods: A prospective cross-sectional study over a period of three months was conducted at the Breast clinic of Komfo Anokye Teaching Hospital, Kumasi, Ghana. Women with histological diagnosis of breast cancer were interviewed using a structured questionnaire. Results: Fifty women with breast cancer were studied with ages between 27 and 75 years with peak between 40-49 years. Majority presented three months after noticing the first symptom, usually a breast lump. Twenty nine (58%) women presented with late stage breast cancer. The commonest histologic type 44(88%) was invasive ductal Carcinoma. There was a strong positive correlation between stage of breast cancer and place of residence (0.4496) but a weak positive correlation between stage of breast cancer and age (0.1684), as was also stage of breast cancer and marital status (0.1143). There was a negative correlation between level of education and stage of presentation (-0.3398). Conclusion: Breast Cancer is common in 40-49 age groups. The incidence of late stage breast cancer is 58% with majority presenting within 7-12 months of onset of first symptoms, mostly breast lumps with invasive ductal carcinoma as the most common histologic type in stage 3. Fear of mastectomy was the main reason for late presentation. Most patients had some knowledge on breast cancer mostly from the radio stations. The stage of Breast cancer was strongly associated with patients’ level of education, residence (distance from facility) and religion
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    Pattern of Childhood Cancers Presenting to the Paediatric Cancer Unit of a Tertiary Hospital in Kumasi, Ghana
    (MedCrave, 2015-11-05) Paintsil, V.; Dogbe, J.; Blay, Nguah; Osei Akoto, A; Osei Tutu, L; Hammond, C
    Introduction: Childhood cancers are increasing in incidence worldwide with geographic differences having an impact on the types of cancers seen. The main aim of this study was to assess the trends in yearly proportions and number of cases seen, to determine age and gender proportions of the types of cancers and types of childhood cancers diagnosed at the cancer unit from 2012 through 2014. The purpose of this study is to set the baseline framework for future research to improve knowledge, clinical care and advocacy programmes for the newly established paediatric cancer unit in KATH in Kumasi, Ghana. Methods: A retrospective study was conducted to review secondary data from the paediatric cancer registry of all patients aged 0-15 years diagnosed with cancer by fine needle aspiration cytology and tissue biopsy at the paediatric cancer unit from 2012-2014. Demographic, anthropometric and clinical data stored in excel was exported to Stata and analysed. Simple descriptive statistics was used and presented in tables. Results: Out of 309 cases, 187(60.5%, 95%CI: 54.8-66.0) were males. Burkitt’s lymphoma (126, 40.8%) was the most common cancer seen followed by Acute Lymphoblastic Leukaemia (31, 10%), Wilm’s Tumour (28, 9.1%), other NonHodgkin’s Lymphoma (28, 9.1%), and retinoblastoma (22, 7.1%). Hodgkin’s Lymphoma was the commonest cancer in the age group 10-15 years, Burkitt ’s lymphoma in the 5-10 year age group and Acute Lymphoblastic Leukaemia in the under 5 years group. Conclusion and Recommendations: There is an observable trend in the progressive increment in the number of cancer cases presenting to the unit over the three years period. Except for the lymphomas, CNS cancers and osteosarcomas which were commoner in the 5-9 years age group, most of the other childhood cancers; leukaemias, renal cancers, soft tissue sarcomas and neuroblatomas were predominant in the 0-4 year age group. Except for a few rare cancers, majority of the common cancers affected more males than females in the paediatric population studied. The Male: Female ratio of all the cases was 1.5:1. The lymphomas were the commonest cancers diagnosed with Burkitt’s lymphoma being the highest among the 5-9 years group. The acute lymphoblastic leukaemias were next to the lymphomas in KATH. Based on these findings, further studies need to be conducted into the specific clinical patterns particularly, the lymphomas and leukaemias for better case management.