Browsing by Author "Saah Ama Selina"

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    Antimicrobial properties of metal piperidine dithiocarbamate complexes against Staphylococcus aureus and Candida albicans
    (ELSEVIER, 2021) Boadi Owusu Nathaniel; Degbevi Mawuli; Badu Mercy; Saah Ama Selina; Kortei Korley Nii; 0000-0001-8038-1453
    In this study, a series of metal piperidine dithiocarbamate complexes (M = Zn, Cu, Co, Fe, Ni, Bi and Ag) were synthesized and characterized using microelemental, 1 HNMR, mass spectrometry and FT-IR analyses. Antimicrobial properties of the complexes were tested against Staphylococcus aureus and Candida albicans in a 96-well plate, using the broth dilution assay. The antimicrobial activity of the complexes was in the order Zn > Co > Cu > Ag = Bi = Ni > Fe against Staphylococcus aureus and Co > Zn > Fe > Ag = Bi = Cu = Ni against Candida albicans. The results indicate that the complexes were effective against the microorganisms at high concentrations.
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    Characterization of latex from trees in the Bobiri forest of Ghana
    (Resaerch Gate, 2019) Saah Ama Selina; Badu Mercy; Boadi Nathaniel; Mensah Baah Michael
    In this study, ten latex samples collected from different trees in the Bobiri forest in the Ashanti region of Ghana, were characterized based on FT-IR, viscosity, protein content, ash content, crosslink density, surface tension and rubber content. The results were compared to that of Hevea brasiliensis, which was used as reference. FT-IR analyses showed peaks at 1637.06 and 2963.61 cm‐1 (C-H bond) and 1450.06 and 1470.00 cm‐1 (C=C bond). These peaks are common with isoprene units (C5H8). Of all the samples, Hevea brasiliensis had the highest rubber contents of 56.18%, and lowest total solids and crosslink density of 14.98 and 0.08 respectively. Pycnanthus angolensis was the most viscous. With respect to total solids and coagulum content, Landolphia hirsuta had the highest percentages of 88.4 and 13% respectively. Based on their properties, these latexes could be used as alternatives to Hevea brasiliensis.
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    Phytochemical screening, antimicrobial and antioxidant properties of assorted Carica papaya leaves in Ghana
    (Journal of Medicinal Plants studies, 2016) Alorkpa Jemima Esther; Boadi Owusu Nathaniel; Badu Mercy; Saah Ama Selina
    The bioactive compounds of the leaves of Carica papaya; solo and solomix were extracted using ethanol and n-hexane, and investigated for the presence of secondary metabolites. Both ethanol and n-hexane extracts revealed the presence of alkaloids. Flavonoids, glycosides and saponins were present in only the ethanol extract whereas tannins were present in the n-hexane extract. The bioactivities of the leaf extracts were attributed to their phytochemical constituents. Antimicrobial activity of the extracts were determined against some human pathogenic bacteria and fungi such as Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Bacillus subtilis and Candida albicans using the agar well diffusion and broth dilution methods with the polar extract being more effective. The ethanol extract demonstrated a significant broad-spectrum antimicrobial activity against both gram-positive and gramnegative bacteria, with the highest activity having a zone of inhibition of 10 mm. Antioxidant activity was determined using the DPPH assay method and the absorbance measured using UV- visible spectrophotometer with ascorbic acid as control. The antioxidant activities of solo and solomix showed IC50 of 1.465x10-2 and 1.364x 10-2 respectively. This study demonstrates the efficacy of ethanolic leaf extracts of C. Papaya as an alternative antibiotic for the development of newer antibacterial agents.