Hydro-ethanol extract of Holarrhena foribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic efects in murine models of acute infammation
| dc.contributor.author | Antwi, Stephen | |
| dc.contributor.author | Oduro‑Mensah, Daniel | |
| dc.contributor.author | Darko Obiri, David | |
| dc.contributor.author | Osafo, Newman | |
| dc.contributor.author | Opoku Antwi, Aaron | |
| dc.contributor.author | Owusu Ansah, Helena | |
| dc.contributor.author | Ocloo, Augustine | |
| dc.contributor.author | Okine, Laud K. N.‑A. | |
| dc.date.accessioned | 2024-05-03T14:48:40Z | |
| dc.date.available | 2024-05-03T14:48:40Z | |
| dc.date.issued | 2022-03-19 | |
| dc.description.abstract | Background: Holarrhena foribunda (G.Don) T.Durand & Schinz stem bark has anecdotal use in Ghanaian folk medi‑ cine for the management of infammatory conditions. This study was conducted to investigate the in vivo anti-infam‑ matory activity of the bark extract using models of acute infammation in male Sprague Dawley rats, C57BL/6 mice and ICR mice. Methods: A 70% hydro-ethanol extract of the stem bark (HFE) was evaluated at doses of 5–500 mg/kg bw. Local ana‑ phylaxis was modelled by the pinnal cutaneous anaphylactic test. Systemic anaphylaxis or sepsis were modeled by compound 48/80 or lipopolysaccharide, respectively. Clonidine-induced catalepsy was used to investigate the efect on histamine signaling. Anti-oedematogenic efect was assessed by induction with carrageenan. Efects on mediators of biphasic acute infammation were studied using histamine and serotonin (early phase) or prostaglandin E2 (late phase). Results: HFE demonstrated anti-infammatory and/or anti-oedematogenic activity comparable to standard doses of aspirin and diclofenac (inhibitors of cyclooxygenases-1 and -2), chlorpheniramine (histamine H1-receptor antagonist), dexamethasone (glucocorticoid receptor agonist), granisetron (serotonin receptor antagonist) and sodium cromogly‑ cate (inhibitor of mast cell degranulation). All observed HFE bioactivities increased with dose. Conclusions: The data provide evidence that the extract of H. foribunda stem bark has anti-anaphylactic and antioedematogenic efects; by interfering with signalling or metabolism of histamine, serotonin and prostaglandin E2 which mediate the progression of infammation. The anti-infammatory and antihistaminic activities of HFE may be relevant in the context of the management of COVID-19. | |
| dc.identifier.citation | Antwi, S., Oduro-Mensah, D., Obiri, D.D. et al. Hydro-ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation. BMC Complement Med Ther 22, 80 (2022). https://doi.org/10.1186/s12906-022-03565-6 | |
| dc.identifier.uri | https://ir.knust.edu.gh/handle/123456789/15699 | |
| dc.language.iso | en_US | |
| dc.publisher | BMC Complementary Medicine and Therapies | |
| dc.title | Hydro-ethanol extract of Holarrhena foribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic efects in murine models of acute infammation | |
| dc.type | Article |