Clinical and Bacteriological Efficacy of Rifampin-Streptomycin Combination for Two Weeks followed by Rifampin and Clarithromycin for Six Weeks for Treatment of Mycobacterium ulcerans Disease

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dc.contributor.authorPhillips, Richard Odame
dc.contributor.authorSarfo, Fred Stephen
dc.contributor.authorAbass, Mohammed K.
dc.contributor.authorAbotsi, Justice
dc.contributor.authorWilson, Tuah
dc.contributor.authorForson, Mark
dc.contributor.authorAmoako, Yaw A.
dc.contributor.authorThompson, William
dc.contributor.authorAsiedu, Kingsley
dc.contributor.authorWansbrough-Jonesc, Mark Wansbrough-Jonesc
dc.date.accessioned2020-01-08T09:40:16Z
dc.date.accessioned2023-04-19T01:34:02Z
dc.date.available2020-01-08T09:40:16Z
dc.date.available2023-04-19T01:34:02Z
dc.date.issued2014-02
dc.descriptionAn article published by Antimicrobial Agents and Chemotherapyp 1161–1166en_US
dc.description.abstractBuruli ulcer, an ulcerating skin disease caused by Mycobacterium ulcerans infection, is common in tropical areas of western Africa. We determined the clinical and microbiological responses to administration of rifampin and streptomycin for 2 weeks followed by administration of rifampin and clarithromycin for 6 weeks in 43 patients with small laboratory-confirmed Buruli lesions and monitored for recurrence-free healing. Bacterial load in tissue samples before and after treatment for 6 and 12 weeks was monitored by semiquantitative culture. The success rate was 93%, and there was no recurrence after a 12-month follow-up. Eight percent had a positive culture 4 weeks after antibiotic treatment, but their lesions went on to heal. The findings indicate that rifampin and clarithromycin can replace rifampin and streptomycin for the continuation phase after rifampin and streptomycin administration for 2 weeks without any apparent loss of efficacy.en_US
dc.identifier.citationAntimicrobial Agents and Chemotherapy p. 1161–1166en_US
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/11839
dc.language.isoenen_US
dc.publisherAntimicrobial Agents and Chemotherapyen_US
dc.titleClinical and Bacteriological Efficacy of Rifampin-Streptomycin Combination for Two Weeks followed by Rifampin and Clarithromycin for Six Weeks for Treatment of Mycobacterium ulcerans Diseaseen_US
dc.typeArticleen_US
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