Effect of Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Anaemia on Malaria Parasitaemia in Children Visiting the Komfo Anokye Teaching Hospital (OPD) in the Kumasi Metropolitan Area, Ghana

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The effect of glueose-6-phosphate dehydrogenase (G6PD) deficiency and sickle-cell anaemia on incidence of malaria parasitaemia amongst children (0-12 years) attending the Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana was determined amongst 215 between April and August, 2007. Both thick and thin blood films wefe prepared and stained using both standard parasitological and haematological procedures. Children visiting the OPD of KATH for medical attention were recruited for the study. Subjects known to have HIV/AIDS were exempted from the study. Of the 215 children investigated, 17 (7.91%) were found to have malaria parasites in their blood with the age group 4-6 years recording the highest (15.09%) frequency rate with a mean parasite » density of 91436.47 jal"1 (p<0.05). Females had a significantly higher (10.2%) (X2 = 3.347, p= 0.0498) malaria incidence rate with a mean parasite density of 75686.1 fil"1 (p< 0.0001), compared to 5.6% malaria incidence rate and 11210.9 mean parasite density in males. Children who had genotype AS (carrier trait) for sickle cell anaemia showed some level of protection against malaria as the genotype had the least degree of parasitaemia, whereas the children heterozygous (partially defective) for G6PD deficiency showed 100% protection against malaria infection with no parasites seen in their blood samples.