Evaluation of antimalarial activity of four (4) cryptolepis sanguinolenta based herbal preparations on plasmodium berghei in mice

Thumbnail Image
Journal Title
Journal ISSN
Volume Title
The antimalarial activity of four Cryptolepis sanguinolenta based herbal preparations namely NBOl, NB02, Cryptoquine and Nibima, were studied using Plasmodium berghei (ANKA) in ICR mice. The herbal preparations were evaluated for chemosupressive activity during an early infection with P. berghei in mice and also for possible repository activity to ascertain whether they could be useful as prophylaxis. Each mouse used in the study was infected with a standard inoculum of 1 x 106 parasitised RBCs intraperitoneally. P. berghei infected mice which were treated with Cryptolepis sanguinolenta based herbal preparations showed chemosuppression in all four herbal preparations for the 4-day suppressive test. Also, the results of the repository activity of the herbal preparations showed that all four herbal preparations have promising repository activity judging by theis ability to reduce parasitemia in mice. Generally, the results of the mean survival time of mice treated with all four herbal preparations under the 4-day tests compares werrwith those treated with chloroquine. The results of the study have shown that all four Cryptolepis sanguinolenta based herbal preparations appear to have both schizontocidal and repository activity against Plasmodium berghei in mice. This implies that all four herbal preparations may be useful in the prevention and treatment of malaria. 
A thesis submitted to the Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology in partial fulfillment of the requirements for the award of Master of Science degree, 2006