Aurantio-obtusin alleviates allergic responses in ovalbumin-induced rhinitis
| dc.contributor.author | Nyarko, Mavis Sersah | |
| dc.contributor.author | Danquah, Cynthia Amaning | |
| dc.contributor.author | Antwi, Aaron Opoku | |
| dc.date.accessioned | 2024-05-03T14:27:08Z | |
| dc.date.available | 2024-05-03T14:27:08Z | |
| dc.date.issued | 2023-11-30 | |
| dc.description.abstract | Allergic rhinitis (AR) is a growing global health concern. Despite being non-fatal, it has a detrimental effect on people’s quality of life and poses a significant economic burden. In this study, we aimed to evaluate the anti-allergic effects of aurantio-obtusin against ovalbumin-induced murine model of allergic rhinitis. Aurantio-obtusin was administered to rats orally after sensitization to ovalbumin. Results of the study suggested that aurantio-obtusin causes a significant reduction in nose rubs and sneeze as compared to the vehicle-treated disease control group. The aurantioobtusin treated group showed a dose-dependent significant reduction in serum TNF-α, IL-4, and IL-6 levels as well as histamine levels in the nasal mucosa. Additionally, it decreased neutrophil and eosinophil numbers in blood of AR rats’. In the nasal tissues of the vehicle-treated rats that were subjected to an OVA challenge, the histology of the nasal mucosa of AR rats revealed aberrant histological changes. A variety of histological abnormalities, including vascular congestion in the nasal mucosa, substantial inflammatory cell infiltration, and obvious alveolar wall oedema were present. In the rats treated with aurantio-obtusin, these characteristics were reversed. Collectively, the findings suggests that aurantio-obtusin could be used to enhance current AR treatment approaches. | |
| dc.identifier.citation | Mavis Sersah Nyarko, Cynthia Amaning Danquah, Aaron Opoku Antwi, Aurantio-obtusin alleviates allergic responses in ovalbumin-induced rhinitis, Scientific African, Volume 23, 2024, e02004, | |
| dc.identifier.issn | 2468-2276 | |
| dc.identifier.uri | https://ir.knust.edu.gh/handle/123456789/15697 | |
| dc.language.iso | en_US | |
| dc.publisher | Scientific African, Elsevier | |
| dc.title | Aurantio-obtusin alleviates allergic responses in ovalbumin-induced rhinitis | |
| dc.type | Article |