Optimal control and comprehensive cost-effectiveness analysis for COVID-19

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dc.contributor.authorAsamoah, Joshua Kiddy K.
dc.contributor.authorOkyere, Eric
dc.contributor.authorAbidemi, Afeez
dc.contributor.authorMoore, Stephen E.
dc.contributor.authorSun, Gui-Quan
dc.contributor.authorJin, Zhen
dc.contributor.authorAcheampong, Edward
dc.contributor.authorGordon, Joseph Frank
dc.contributor.orcid0000-0002-7066-246X
dc.date.accessioned2024-11-20T12:37:41Z
dc.date.available2024-11-20T12:37:41Z
dc.date.issued2022-01
dc.descriptionThis article is published by Elsevier 2022 and is also available at https://doi.org/10.1016/j.rinp.2022.105177
dc.description.abstractCost-effectiveness analysis is a mode of determining both the cost and economic health outcomes of one or more control interventions. In this work, we have formulated a non-autonomous nonlinear deterministic model to study the control of COVID-19 to unravel the cost and economic health outcomes for the autonomous nonlinear model proposed for the Kingdom of Saudi Arabia. We calculated the strength number and noticed the strength number is less than zero, meaning the proposed model does not capture multiple waves, hence to capture multiple wave new compartmental model may require for the Kingdom of Saudi Arabia. We proposed an optimal control problem based on a previously studied model and proved the existence of the proposed optimal control model. The optimality system associated with the non-autonomous epidemic model is derived using Pontryagin’s maximum principle. The optimal control model captures four time-dependent control functions, thus, 𝑢1-practising physical or social distancing protocols; 𝑢2-practising personal hygiene by cleaning contaminated surfaces with alcohol-based detergents; 𝑢3-practising proper and safety measures by exposed, asymptomatic and symptomatic infected individuals; 𝑢4-fumigating schools in all levels of education, sports facilities, commercial areas and religious worship centres. We have performed numerical simulations to investigate extensive cost-effectiveness analysis for fourteen optimal control strategies. Comparing the control strategies, we noticed that; Strategy 1 (practising physical or social distancing protocols) is the most costsaving and most effective control intervention in Saudi Arabia in the absence of vaccination. But, in terms of the infection averted, we saw that strategy 6, strategy 11, strategy 12, and strategy 14 are just as good in controlling COVID-19.
dc.description.sponsorshipKNUST
dc.identifier.citationResults in Physics 33 (2022) 105177
dc.identifier.urihttps://doi.org/10.1016/j.rinp.2022.105177
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/15964
dc.language.isoen
dc.publisherElsevier
dc.titleOptimal control and comprehensive cost-effectiveness analysis for COVID-19
dc.typeArticle
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