A Retrospective Evaluation of Ciprofloxacin use at Kwame Nkrumah University of Science and Technology (KNUST) Hospital, Kumasi

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Back ground Ciprofloxacin has been used for chemotherapy of bacterial infections over the years in Ghana. However not much is known about the quality of its use regarding the appropriateness of clinical indication, dosages administered, dose frequency, duration and potential for interactions with multivalent cations Objective The present study was therefore undertaken to evaluate its use in respect of the above mentioned parameters excluding the first. Methods This was a cross-sectional retrospective study involving two thousand patients’ charts that covered a three month period (1st Oct 2004 to 31st December 2004) at the KNUST Hospital. Patient records were examined to assess the appropriateness of ciprofloxacin use with respect to the dose, dose frequency, dose duration and the potential for drug –drug interactions with multivalent cations (MVCs). Results It was found out that the dose for all the justified indications of UTI, bone and joint infection, enteric fever and enteritis was 500 mg. The dose frequency in all the above cases was twelve hourly. The potential for drug –drug interaction with respect to multivalent cations was virtually absent. However the duration of treatment for all the justified cases did not meet standard criteria.
A Thesis Submitted to the Department of Clinical and Social Pharmacy, Kwame Nkrumah University of Science and Technology in partial fulfillment of the requirements for the award of Master of Science of