Peripheral insulin resistance rather than beta cell dysfunction accounts for geographical differences in impaired fasting blood glucose among sub-Saharan African individuals: findings from the RODAM study
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Date
2017
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SPRINGER
Abstract
Aims/hypothesis The aim of this study was to assess the extent
to which insulin resistance and beta cell dysfunction account
for differences in impaired fasting blood glucose (IFBG)
levels in sub-Saharan African individuals living in different
locations in Europe and Africa. We also aimed to identify
determinants associated with insulin resistance and beta cell
dysfunction among this population.
Methods Data from the cross-sectional multicentre Research
on Obesity and Diabetes among African Migrants (RODAM)
study were analysed. Participants included Ghanaian individuals
without diabetes, aged 18–96 years old, who were residing in
Amsterdam (n = 1337), Berlin (n = 502), London (n = 961),
urban Ghana (n= 1309) and rural Ghana (n= 970). Glucose
and insulin were measured in fasting venous blood samples.
Anthropometrics were assessed during a physical examination.
Questionnaires were used to assess demographics, physical
activity, smoking status, alcohol consumption and energy intake.
Insulin resistance and beta cell function were determined using
homeostatic modelling (HOMA-IR and HOMA-B, respectively).
Logistic regression analysis was used to study the contribution of
HOMA-IR and inverse HOMA-B (beta cell dysfunction)
to geographical differences in IFBG (fasting glucose
5.6–6.9 mmol/l). Multivariate linear regression analysis was
used to identify determinants associated with HOMA-IR and
inverse HOMA-B.
Description
This article is published Springer.
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Citation
Diabetologia (2017) 60:854–864 DOI 10.1007/s00125-017-4216-4