Artesunate-Amodiaquine and Artemether Lumefantrine Therapies and Selection of Pfcrt and Pfmdr1 Alleles in Nanoro, Burkina Faso

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dc.contributor.authorSondo Paul
dc.contributor.authorDerra Karim
dc.contributor.authorOwusu-Dabo Ellis
dc.contributor.authorTarnagda Zekiba
dc.contributor.authorSorgho Hermann
dc.contributor.authorOuédraogo Jean-Bosco....et al
dc.date.accessioned2023-12-06T13:33:56Z
dc.date.available2023-12-06T13:33:56Z
dc.date.issued2016
dc.descriptionThis article is published by Plos One and is also available at https://doi.org/10.1371/journal.pone.0151565
dc.description.abstractThe adoption of Artemisinin based combination therapies (ACT) constitutes a basic strategy for malaria control in sub-Saharan Africa. Moreover, since cases of ACT resistance have been reported in South-East Asia, the need to understand P. falciparum resistance mecha nism to ACT has become a global research goal. The selective pressure of ACT and the possibility that some specific Pfcrt and Pfmdr1 alleles are associated with treatment failures was assessed in a clinical trial comparing ASAQ to AL in Nanoro. Dried blood spots col lected on Day 0 and on the day of recurrent parasitaemia during the 28-day follow-up were analyzed using the restriction fragments length polymorphism (PCR-RFLP) method to detect single nucleotide polymorphisms (SNPs) in Pfcrt (codon76) and Pfmdr1 (codons 86, 184, 1034, 1042, and 1246) genes. Multivariate analysis of the relationship between the presence of Pfcrt and Pfmdr1 alleles and treatment outcome was performed. AL and ASAQ exerted opposite trends in selecting Pfcrt K76T and Pfmdr1-N86Y alleles, raising the poten tial beneficial effect of using diverse ACT at the same time as first line treatments to reduce the selective pressure by each treatment regimen. No clear association between the pres ence of Pfcrt and Pfmdr1 alleles carried at baseline and treatment failure was observed
dc.description.sponsorshipKNUST
dc.identifier.citationSondo P, Derra K, Diallo Nakanabo S, Tarnagda Z, Kazienga A, Zampa O, et al. (2016) Artesunate-Amodiaquine and Artemether Lumefantrine Therapies and Selection of Pfcrt and Pfmdr1 Alleles in Nanoro, Burkina Faso
dc.identifier.uri10.1371/journal.pone.0151565
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/14665
dc.language.isoen
dc.publisherPLOS ONE
dc.titleArtesunate-Amodiaquine and Artemether Lumefantrine Therapies and Selection of Pfcrt and Pfmdr1 Alleles in Nanoro, Burkina Faso
dc.typeArticle
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