Veterinary Drug Residues in Chicken Eggs from Some Selected Poultry Farms in the Kumasi Metropolis, Kwabre East and Offinso Districts of the Ashanti Region

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Multiresidue analyses of veterinary drugs were determined in commercial eggs from the Offinso, Kumasi Metropolis and the Kwabre East District in the Ashanti Region. A total of 200 table egg samples were collected for albendazole, chloramphenicol, levamisole, oxytetracycline, piperazine, sulphamethoxazole, sulphathiazole and tiamulin residuesfrom 5 poultry farms. Whole eggs were homogenized in acetonitrile, extracts evaporated and residues dissolved in mobile phase. The fats were removed using hexane. Extracts were analyzed by solid phase reverse phase high performance liquid chromatography with photodiode array detector. Results showed that Albendazole was the most frequently detected in all the 200 samples taken from the five farms in the three districts which occurred at an average concentration of 116.1± 2.30 µg/kg. Chloramphenicol was also detected at an average concentration of 26.6 ± 0.39µg/kg. Levamisole was recorded at an average concentration of 14.7 ± 0.26 µg/kg. Oxytetracycline residues registered an average concentration of 19.8 ± 0.47µg/kg.Piperazine was detected at an average concentration of 40.00 ± 0.80 µg/kg. The two sulphonamides,sulphamethoxazole and sulphathiazole had detectable concentrations of 17.05 ± 0.34µg/kg and32.50 ± 0.42 µg/kg respectively. The least detectable residue in all the five farms was tiamulin which had a detectable concentration of 0.95± 0.04 µg/kg. Detectable levels of all the drug residues were below their maximum residual limit given by the Joint FAO/WHO Expert Committee on Food Additives (JECFA).However the residues may accumulate to higher levels in human beings making them dangerous to human health.  
A thesis submitted to the Department Of Chemistry, Faculty Of Science, Kwame Nkrumah University Of Science And Technology in partial fulfilment of the requirements of the degree of Mphil Degree in Analytical Chemistry, 2014