Reply to “Compliance with Antimicrobial Therapy for Buruli Ulcer”

Recently, Klis et al. conducted an audit of Buruli ulcer case record forms of patients managed under routine care conditions in a Buruli ulcer treatment center and showed a surprisingly high rate (54%) of noncompliance with therapy (1). Incomplete adherence to treatment has been identified as the most serious problem in tuberculosis control (2) and a major obstacle to the elimination of the disease (3). To ensure adherence to therapy in our study, several approaches were incorporated into patient care. These included issuing medication in 2-weekly batches, allowing the clinician several opportunities to assess adherence during therapy.
An article published by Antimicrobial Agents and Chemotherapy and available at doi:10.1128/AAC.03874-14
Antimicrobial Agents and Chemotherapy Volume 58 Number 10