Hypoglycaemic activity and other pharmacological properties of tragia tennifolia (fam. euphorbiaceae)
| dc.contributor.author | Kuffour, George Asumeng | |
| dc.date.accessioned | 2011-12-14T23:44:42Z | |
| dc.date.accessioned | 2023-04-19T08:31:36Z | |
| dc.date.available | 2011-12-14T23:44:42Z | |
| dc.date.available | 2023-04-19T08:31:36Z | |
| dc.date.issued | 2001 | |
| dc.description | A thesis submitted to the College of Health Sciences, Kwame Nkrumah University of Science and Technology, in partial fulfilment of the requirements for the award of Master of Science in Pharmacy | en_US |
| dc.description.abstract | The hypoglycaemic effect of Tragia tennfolia was studied in alloxan-induced diabetic rats, rats subjected to oral glucose tolerance test (OGTT) and rats subjected to a fasting plasma glucose test (FPG). An infusion of T. tennifolia insignificantly reduced (P > 0.05) glycaemic levels alongside glibenclamide (an oral hypoglycaemic agent) and metformin (an euglycaemic agent ) and insignificantly (P > 0.05) affected some diabetes related parameters (polyuria, polyphagia polydipsia, glucosuria and body weight) measured in alloxan-induced diabetes mellitus as compared to insulin. The area under the OGTT curve reduced significantly with the peak plasma glucose concentration reducing by 60 % on administration of Ttennfolia to normal rats. The FPG in normal rats was also reduced by 33.1 % after 5 hours. This indicates that an infusion of Tragia tennfolia has prominent hypoglycaemic effect in normal rats. The drug is effective in decreasing hyperglycaemia in non-insulin-dependent diabetes mellitus (NIDDM) at a dose level of 53 mg/kg but not in insulin-dependent diabetes mellitus (IDDM). Experiments on the isolated guinea-pig ileum, the rat annococcygeus muscle and the rat uterus preparations indicates that Tragia tennfolia has muscarinic, histaminic, α-adrenergic and some β-adrenergic receptor activity with its muscarinic activity possibly accounting for the hypoglycaemic effect. No acute toxic symptoms were observed after an oral administration of up to 8 g/kg of Tragia tennfolia extract and sub-acute studies revealed no damage to vital organs like the liver and kidney. | en_US |
| dc.description.sponsorship | KNUST | en_US |
| dc.identifier.uri | https://ir.knust.edu.gh/handle/123456789/2405 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartofseries | 3030; | |
| dc.title | Hypoglycaemic activity and other pharmacological properties of tragia tennifolia (fam. euphorbiaceae) | en_US |
| dc.type | Thesis | en_US |
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