The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa
dc.contributor.author | Park Eun Se | |
dc.contributor.author | Pham Thanh Duy | |
dc.contributor.author | Owusu-Dabo Ellis | |
dc.contributor.author | Aseffa Abraham....et al | |
dc.date.accessioned | 2023-12-13T11:26:57Z | |
dc.date.available | 2023-12-13T11:26:57Z | |
dc.date.issued | 2018 | |
dc.description | This article is published by Springer Nature and is also available at https://doi.org/10.1038/s41467-018-07370-z | |
dc.description.abstract | There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global S. Typhi genomic framework. Despite the broad genetic diversity, the majority of organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), and 2.3.2 (29/249; 12%). Genotypes 4.3.1 and 3.1.1 are confined within East and West Africa, respectively. MDR phenotype is found in over 50% of organisms restricted within these dominant genotypes. High incidences of MDR S. Typhi are calculated in locations with a high burden of typhoid, specifically in children aged <15 years. Antimicrobial stewardship, MDR surveillance, and the introduction of typhoid conjugate vaccines will be critical for the control of MDR typhoid in Africa. | |
dc.description.sponsorship | KNUST | |
dc.identifier.citation | Park, S.E., Pham, D.T., Boinett, C. et al. The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa. Nat Commun 9, 5094 (2018). https://doi.org/10.1038/s41467-018-07370-z | |
dc.identifier.uri | 10.1038/s41467-018-07370-z | |
dc.identifier.uri | https://ir.knust.edu.gh/handle/123456789/14826 | |
dc.language.iso | en | |
dc.publisher | Springer Nature | |
dc.title | The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa | |
dc.type | Article |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa..pdf
- Size:
- 1.31 MB
- Format:
- Adobe Portable Document Format
- Description:
License bundle
1 - 1 of 1
Loading...
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed to upon submission
- Description: