Antimicrobial and Phytochemical Properties of Alstonia Boonei Extracts
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Date
2015-01-01
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Publisher
OMICS Publishing Group
Abstract
Alstonia boonei De wild is a major spice crop grown abundantly in Ghana and other tropical countries. In this study
we have carried out phytochemical analysis and antimicrobial investigation of ethanol and aqueous extracts of the root
of Alstonia boonei against a panel of clinically significant bacterial and fungal strains. Four Gram positive and Gram
negative bacteria namely Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus were
subjected to test the antimicrobial activity along with one fungi namely, Candida albicans. The ethanol and aqueous
extracts of root of Alstonia boonei were subjected to microbial susceptibility assays using agar well diffusion method.
Phytochemical screening was done to test the presence of phytochemicals responsible for the antimicrobial potential
of roots of Alstonia boonei. The results of the phytochemical studies revealed the presence alkaloids, cyanogenetic
glycosides, flavonoids, terpenoids and steroids and saponins. Susceptibility testing by disc diffusion assay revealed
significant antimicrobial activity of methanol and aqueous extracts of the roots against the pathogens tested. The
minimum inhibitory concentrations (MIC) of the various extracts by Agar Dilution method ranged from 3.0 to 10.0 mg/ml.
The ethanol extracts exhibited better antimicrobial activity than aqueous extract. The study findings provide supportive
evidence for the use of Alstonia boonei in traditional medicines.
Description
An article published by OMICS Publishing Group and also available at doi: 10.4172/2161-
0401.1000137
Keywords
Alstonia boonei;, Antimicrobial activity;, Agar well diffusion;, Phytochemical
Citation
Citation: Opoku F, Akoto O (2014) Antimicrobial and Phytochemical Properties of Alstonia Boonei Extracts. Organic Chem Curr Res 1:137. doi: 10.4172/2161- 0401.100013