African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent

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dc.contributor.authorMartini, Rachel
dc.contributor.authorDelpe, Princesca
dc.contributor.authorChu, Timothy R.
dc.contributor.authorArora, Kanika
dc.contributor.authorBrittany, Lord
dc.contributor.authorAitpillar, Francis S.
dc.contributor.authoret.al....
dc.date.accessioned2024-08-02T14:25:09Z
dc.date.available2024-08-02T14:25:09Z
dc.date.issued2022-11
dc.descriptionThis is an article published in Cancer Discovery, November, 2022
dc.description.abstractWomen of sub-Saharan African descent have disproportionately higher incidence of triple-negative breast cancer (TNBC) and TNBC-specific mortality across all populations. Population studies show racial differences in TNBC biology, including higher prevalence of basal-like and quadruple-negative subtypes in African Americans (AA). However, previous investigations relied on self-reported race (SRR) of primarily U.S. populations. Due to heterogeneous genetic admixture and biological consequences of social determinants, the true association of African ancestry with TNBC biology is unclear. To address this, we conducted RNA sequencing on an international cohort of AAs, as well as West and East Africans with TNBC. Using comprehensive genetic ancestry estimation in this African-enriched cohort, we found expression of 613 genes associated with African ancestry and 2,000+ associated with regional African ancestry. A subset of African-associated genes also showed differences in normal breast tissue. Pathway enrichment and deconvolution of tumor cellular composition revealed that tumor-associated immunologic profiles are distinct in patients of African descent.
dc.description.sponsorshipKNUST
dc.identifier.citationCancer Discovery, November, 2022
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/15890
dc.language.isoen
dc.publisherCancer Discovery
dc.titleAfrican Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
dc.typeArticle
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