Spatial heterogeneity of malaria in Ghana: a cross-sectional study on the association between urbanicity and the acquisition of immunity
| dc.contributor.author | Frank Clemens | |
| dc.contributor.author | Krumkamp Ralf | |
| dc.contributor.author | Owusu-Dabo Ellis | |
| dc.contributor.author | Sarpong Nimako | |
| dc.contributor.author | Sothmann Peter......et al | |
| dc.date.accessioned | 2023-12-13T10:08:19Z | |
| dc.date.available | 2023-12-13T10:08:19Z | |
| dc.date.issued | 2016 | |
| dc.description | This article is published by BioMed Central. | |
| dc.description.abstract | Background: Malaria incidence has declined considerably over the last decade. This is partly due to a scale-up of control measures but is also attributed to increasing urbanization. This study aimed to analyse the association between malaria and urbanization and the effect of urbanicity on the acquisition of semi-immunity. Methods: In 2012, children with fever presenting to St Michael’s Hospital Pramso/Ghana were recruited. The malaria positive-fraction (MPF) of fever cases was calculated on community-level to approximate the malaria risk. The mean age of malaria cases was calculated for each community to estimate the acquisition of semi-immunity. The level of urbanicity for the communities was calculated and associations between MPF, urbanicity and immunity were modelled using linear regression. Results: Twenty-six villages were included into the study with a mean MPF of 35 %. A linear decrease of 5 % (95 % CI: 4–6 %) in MPF with every ten-point increase in urbanicity was identified. The mean age of malaria patients increased by 2.9 months (95 % CI: 1.0–4.8) with every ten-point increase in urbanicity. Discussion: The results confirm an association between an increase in urbanicity and declining malaria risk and dem‑ onstrate that the acquisition of semi-immunity is heterogeneous on a micro-epidemiological scale and is associated with urbanicity | |
| dc.description.sponsorship | KNUST | |
| dc.identifier.citation | Frank et al. Malar J (2016) 15:84 DOI 10.1186/s12936-016-1138-4 | |
| dc.identifier.uri | 10.1186/s12936-016-1138-4 | |
| dc.identifier.uri | https://ir.knust.edu.gh/handle/123456789/14816 | |
| dc.language.iso | en | |
| dc.publisher | BioMed Central | |
| dc.title | Spatial heterogeneity of malaria in Ghana: a cross-sectional study on the association between urbanicity and the acquisition of immunity | |
| dc.type | Article |