Dynamics of the Cytokine Response to Mycobacterium ulcerans during Antibiotic Treatment for M. ulcerans Disease (Buruli Ulcer) in Humans

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dc.contributor.authorSarfo, Fred Stephen
dc.contributor.authorPhillips, Richard Odame
dc.contributor.authorAmpadu, E.
dc.contributor.authorSarpong, F.
dc.contributor.authorAdentwe, E.
dc.contributor.authoret.al
dc.date.accessioned2020-01-08T12:27:44Z
dc.date.accessioned2023-04-19T01:36:56Z
dc.date.available2020-01-08T12:27:44Z
dc.date.available2023-04-19T01:36:56Z
dc.date.issued2009-01
dc.descriptionAn article by American Society for Microbiologyen_US
dc.description.abstractWe have studied the evolution of the gamma interferon (IFN- ) and interleukin 10 (IL-10) responses after Mycobacterium ulcerans sonicate stimulation of whole blood from patients with early M. ulcerans lesions during treatment with rifampin and streptomycin for 8 weeks. Among the 26 patients, secretion of IFN- increased during treatment, with a significant increase at 4 weeks and a further increase after 8 weeks overall. The increase was more rapid in patients with large or ulcerative lesions, becoming significant by 4 weeks. For small lesions, there was only a minor increase, which did not reach significance. There was no significant change in the median IL-10 response during antibiotic therapy, and there was no inverse correlation between IFN- and IL-10 responses. These results demonstrate that an IFN- secretory response to M. ulcerans developed, independently of IL-10 secretion, in patients whose M. ulcerans disease healed during antibiotic therapy.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.citationAmerican Society for Microbiology Vol. 16, No. 1en_US
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/11851
dc.language.isoenen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.titleDynamics of the Cytokine Response to Mycobacterium ulcerans during Antibiotic Treatment for M. ulcerans Disease (Buruli Ulcer) in Humansen_US
dc.typeArticleen_US
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