Investigation of serum level relationship of pro-inflammatory and anti-inflammatory cytokines with vitamin D among healthy Ghanaian population
| dc.contributor.author | Antwi, Maxwell Hubert | |
| dc.contributor.author | Sakyi, Samuel Asamoah | |
| dc.contributor.author | Appiah, Seth Christopher Yaw | |
| dc.contributor.author | Buckman, Tonnies Abeku | |
| dc.contributor.orcid | 0000-0002-5229-0340 | |
| dc.date.accessioned | 2024-05-29T15:07:58Z | |
| dc.date.available | 2024-05-29T15:07:58Z | |
| dc.date.issued | 2024 | |
| dc.description | This article is published by BMC Publisher and is also available at https://doi.org/10.1186/s13104-024-06721-y | |
| dc.description.abstract | Background The interplay between vitamin D status and inflammatory cytokines in a supposedly sufficient sunshine environment has not well been evaluated. The study sought to determine their association. Methods This cross-sectional study involved 500 healthy adult blood donors from some selected hospitals in Ghana enrolled from June to November 2016. Venous blood samples were obtained from participants, 25(OH)D, TNF-alpha, IFN-gamma, and IL 10 were measured using enzyme linked immunosorbent assay (ELISA) technique. Serum levels of 25(OH)D<20ng/ml were classified as being deficient or low. Results The average age of the participants was 27.97 years. No statistically significant association was established between 25(OH) D status, mean age (p=0.1693), and gender (p=0.5461) of study participants. Similarly, the median 25(OH) D (p=0.8392), IL-10 (p=0.5355), TNF-alpha (p=0.9740), and IFN-gamma (p=0.6908) were not significantly different across gender. There was a significantly increased levels of TNF-alpha (p<0.0001) and IFN-gamma (p<0.0001) among participants with 25(OH) D deficiency compared to those without deficiency. Concurrently, participants with 25(OH)D deficiency had a significantly reduced levels of IL-10 (p<0.0001) compared to those without 25 (OH) D deficiency. The most accurate biochemical markers for identifying 25 (OH) D deficiency were IFN gamma (AUC=0.879; p<0.0001) followed by TNF-gamma (AUC=0.849; p<0.0001) and IL-10 (AUC=0.707; p<0.0001). Conclusion There was a significant association between vitamin D levels and pro-inflammatory cytokines (TNF alpha, IFN-gamma) and anti-inflammatory cytokine (IL 10) among healthy Ghanaian populace. | |
| dc.description.sponsorship | KNUST | |
| dc.identifier.citation | BMC Research Notes (2024) 17:64 | |
| dc.identifier.uri | 10.1186/s13104-024-06721-y | |
| dc.identifier.uri | https://ir.knust.edu.gh/handle/123456789/15739 | |
| dc.language.iso | en | |
| dc.publisher | BMC Publisher | |
| dc.title | Investigation of serum level relationship of pro-inflammatory and anti-inflammatory cytokines with vitamin D among healthy Ghanaian population | |
| dc.type | Article |