CD27 expression of T-cells discriminates IGRA-negative TB patients from healthy contacts in Ghana

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dc.contributor.authorPhillips, Richard Odame
dc.contributor.authorAdankwah, Ernest
dc.contributor.authorGüler, Alptekin
dc.contributor.authorMayatepek, Ertan
dc.contributor.authorNausch, Norman
dc.contributor.authoret. al
dc.date.accessioned2020-01-14T17:12:28Z
dc.date.accessioned2023-04-19T01:49:30Z
dc.date.available2020-01-14T17:12:28Z
dc.date.available2023-04-19T01:49:30Z
dc.date.issued2019
dc.descriptionAn article published by Elsevier Masson SASen_US
dc.description.abstractIFN-g release assays (IGRAs) have suboptimal sensitivity for detection of Mycobacterium tuberculosis (Mtb) infection and cannot discriminate between tuberculosis (TB) patients and healthy -potentially Mtb infected- contacts (HCs). In a case-control study, we determined T-cell phenotypes of IGRAs in TB patients (n ¼ 20) and HCs (n ¼ 20) from Ghana. CD27 expression of T-cells was significantly lower in TB patients as compared to HCs independent from Mtb-specificity. CD27 expression discriminated both study groups - including TB patients with low or indeterminate IGRA results - effectively. We conclude that CD27 is a promising biomarker for diagnosis of TB patients with inconclusive IGRA results.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.citationElsevier Masson SAS doi.org/10.1016/j.micinf.2019.07.003en_US
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/11928
dc.language.isoenen_US
dc.publisherElsevier Masson SASen_US
dc.subjectTuberculosisen_US
dc.subjectHealthy contactsen_US
dc.subjectIFN-g release assayen_US
dc.subjectCD27en_US
dc.subjectT-cellen_US
dc.titleCD27 expression of T-cells discriminates IGRA-negative TB patients from healthy contacts in Ghanaen_US
dc.typeArticleen_US
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