CD27 expression of T-cells discriminates IGRA-negative TB patients from healthy contacts in Ghana
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Date
2019
Authors
Phillips, Richard Odame
Adankwah, Ernest
Güler, Alptekin
Mayatepek, Ertan
Nausch, Norman
et. al
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Masson SAS
Abstract
IFN-g release assays (IGRAs) have suboptimal sensitivity for detection of Mycobacterium tuberculosis
(Mtb) infection and cannot discriminate between tuberculosis (TB) patients and healthy -potentially Mtb
infected- contacts (HCs). In a case-control study, we determined T-cell phenotypes of IGRAs in TB patients
(n ¼ 20) and HCs (n ¼ 20) from Ghana. CD27 expression of T-cells was significantly lower in TB
patients as compared to HCs independent from Mtb-specificity. CD27 expression discriminated both
study groups - including TB patients with low or indeterminate IGRA results - effectively. We conclude
that CD27 is a promising biomarker for diagnosis of TB patients with inconclusive IGRA results.
Description
An article published by Elsevier Masson SAS
Keywords
Tuberculosis, Healthy contacts, IFN-g release assay, CD27, T-cell
Citation
Elsevier Masson SAS doi.org/10.1016/j.micinf.2019.07.003